Frédéric also specializes in molecular biology, which he has been teaching to undergraduates at Université Laval's Certificat Universitaire en Biotechnologie since 2019. He is also a research member of INAF (U.Laval) and of the CISSS-Chaudière-Appalaches research center.

Frédéric is also an FRQ-supported researcher for his work on non-invasive physiological sensors.

Frédéric has been a researcher at TransBIOTech since 2017 and is also Head of the Pharmaceutical Sciences Department.

‍

TRAININGS

- Microprogramme de^3e cycle en Éducation Supérieure - Université de Sherbrooke

- Ph.D.- Biochemistry - Université de Sherbrooke

- B.Sc.- Pharmacology - Université de Sherbrooke

‍

RESEARCH THEMES

ADME/ PK-PD in vivo studies

Cell-based studies (transfections; cell assays; CRISPR)

In vitro biochemical studies

In vivo fluorescence imaging

Efficacy of immunomodulators of the innate immune response

Delivery of Pharmaceutical Assets

Development of molecular sensors

Pharmacology of proprotein convertase inhibitors

Histological analysis

PROJECTS FINANCED

No items found.

Publications

In Situ Non-InvasiveImaging of Neutrophil Myeloperoxidase and Skin Reactive Oxygen Species inExperimental Murine Atopic Dermatitis; S Babity, S Pei, J Galimi, V Lapointe, D Brambilla, F Couture; Advanced Sensor Research 2 (9), 2300015

Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo. Katarina Kulhankova, Soumba Traore, Xue Cheng, Hadrien Benk-Fortin, Stéphanie Hallée, Mario Harvey, Joannie Roberge, Frédéric Couture, Sajeev Kohli, Thomas J. Gross, David K. Meyerholz, Garrett R. Rettig, Bernice Thommandru, Gavin Kurgan, Christine Wohlford-Lenane, Dennis J.Hartigan-O'Connor, Gregory A. Newby, David R. Liu, Alice F. Tarantal, David Guay, Paul B. McCray, Jr. Nature Communications 2023 Dec 5;14(1):8051.

‍

Intralesional Treatment of Basal Cell Carcinoma in a Genetically Inducible Mouse Model; N Messier, F Couture, V Théberge, M Harvey, K Kobayashi; SKIN The Journal of Cutaneous Medicine 7 (2), s172-s172

Granulocyte pro-myeloperoxidase is redundantly processed by proprotein convertase furin and PC7 in HL-60 cells; V Lapointe, F Couture; Biochemistry and Cell Biology 102 (3), 275-284

‍

Therapeutic Targeting of the Proteolytic Enzymes; F Couture; International Journal of Molecular Sciences 24 (1), 521

A Naked Eye-Invisible Ratiometric Fluorescent Microneedle Tattoo for Real-Time Monitoring of Inflammatory Skin Conditions; S Babity, F Couture, EVR Campos, S Hedtrich, R Hagen,D Fehr, M Bonmarin, D Brambilla; Advanced Healthcare Materials 11 (6), 2102070

Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function; S Babity, AK Polomska, F Couture, M Bonmarin, D Fehr, M Detmar, D Brambilla; Journal of Controlled Release 327, 350-359

‍