Team

Frédéric Couture

Researcher - pharmacology, Preclinical Research Manager
Pharmacology

EXPERTISE

- Preclinical Pharmacology

- Oncology

- Molecular biology and genetic engineering

- Stable and transient expression and repression

- Biomarkers

- Imaging

- Experimental pharmacology

- Proteolysis and enzymology

- Pharmaceutical development: in cellulo - in vivo transition

BIOGRAPHY

Frédéric holds a PhD in biochemistry (Université de Sherbrooke, 2018) and specializes in preclinical pharmacology.

Frédéric also specializes in molecular biology, which he has been teaching to undergraduates at Université Laval's Certificat Universitaire en Biotechnologie since 2019. He is also a research member of INAF (U.Laval) and of the CISSS-Chaudière-Appalaches research center.

Frédéric is also an FRQ-supported researcher for his work on non-invasive physiological sensors.

Frédéric has been a researcher at TransBIOTech since 2017 and is also Head of the Pharmaceutical Sciences Department.

TRAININGS

- Microprogramme de3e cycle en Éducation Supérieure - Université de Sherbrooke

- Ph.D.- Biochemistry - Université de Sherbrooke

- B.Sc.- Pharmacology - Université de Sherbrooke

RESEARCH THEMES

ADME/ PK-PD in vivo studies
Cell-based studies (transfections; cell assays; CRISPR)
In vitro biochemical studies
In vivo fluorescence imaging
Efficacy of immunomodulators of the innate immune response
Delivery of Pharmaceutical Assets
Development of molecular sensors
Pharmacology of proprotein convertase inhibitors
Histological analysis
Cutting-edge technology

PROJECTS FINANCED

No items found.

Publications

In Situ Non-InvasiveImaging of Neutrophil Myeloperoxidase and Skin Reactive Oxygen Species inExperimental Murine Atopic Dermatitis; S Babity, S Pei, J Galimi, V Lapointe, D Brambilla, F Couture; Advanced Sensor Research 2 (9), 2300015

 

Shuttle Peptide Delivers Base Editor RNPs to Rhesus Monkey Airway Epithelial Cells In Vivo. Katarina Kulhankova, Soumba Traore, Xue Cheng, Hadrien Benk-Fortin, Stéphanie Hallée, Mario Harvey, Joannie Roberge, Frédéric Couture, Sajeev Kohli, Thomas J. Gross, David K. Meyerholz, Garrett R. Rettig, Bernice Thommandru, Gavin Kurgan, Christine Wohlford-Lenane, Dennis J.Hartigan-O'Connor, Gregory A. Newby, David R. Liu, Alice F. Tarantal, David Guay, Paul B. McCray, Jr. Nature Communications 2023 Dec 5;14(1):8051.

 Intralesional Treatment of Basal Cell Carcinoma in a Genetically Inducible Mouse Model; N Messier, F Couture, V Théberge, M Harvey, K Kobayashi; SKIN The Journal of Cutaneous Medicine 7 (2), s172-s172

 

Granulocyte pro-myeloperoxidase is redundantly processed by proprotein convertase furin and PC7 in HL-60 cells; V Lapointe, F Couture; Biochemistry and Cell Biology 102 (3), 275-284

Therapeutic Targeting of the Proteolytic Enzymes; F Couture; International Journal of Molecular Sciences 24 (1), 521

 

A Naked Eye-Invisible Ratiometric Fluorescent Microneedle Tattoo for Real-Time Monitoring of Inflammatory Skin Conditions; S Babity, F Couture, EVR Campos, S Hedtrich, R Hagen,D Fehr, M Bonmarin, D Brambilla; Advanced Healthcare Materials 11 (6), 2102070

 

Rational design of a fluorescent microneedle tattoo for minimally invasive monitoring of lymphatic function; S Babity, AK Polomska, F Couture, M Bonmarin, D Fehr, M Detmar, D Brambilla; Journal of Controlled Release 327, 350-359

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